Commentary: Acetaldehyde and Epithelial-to-Mesenchymal Transition in Colon

Elamin and colleagues in this issue report that acetaldehyde activates Snail, a transcription factor involved in epithelial‐to‐mesenchymal transition, in an intestinal epithelium. Snail mediates acetaldehyde‐induced tight junction disruption and increase in paracellular permeability. Results of this...

Full description

Saved in:
Bibliographic Details
Published in:Alcoholism, clinical and experimental research clinical and experimental research, 2014-02, Vol.38 (2), p.309-311
Main Author: Rao, Radhakrishna K.
Format: Article
Language:English
Subjects:
Acetaldehyde - toxicity
Cancer
Colon
Epithelial-Mesenchymal Transition - drug effects
Ethanol
Humans
Intestinal Mucosa - drug effects
Metastasis
Small intestine
Snail Family Transcription Factors
Transcription Factors - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Elamin and colleagues in this issue report that acetaldehyde activates Snail, a transcription factor involved in epithelial‐to‐mesenchymal transition, in an intestinal epithelium. Snail mediates acetaldehyde‐induced tight junction disruption and increase in paracellular permeability. Results of this study and other previous studies raise several important questions. This commentary addresses these questions by discussing the acetaldehyde concentration in colon, disruption of epical junctional complexes in the intestinal epithelium by acetaldehyde, and the consequence of long‐term exposure to acetaldehyde on colonic epithelial regeneration, carcinogenesis, and metastases. The precise role of acetaldehyde in colonic epithelial modifications and promotion of colorectal cancers still remains to be understood.
ISSN:0145-6008
1530-0277
DOI:10.1111/acer.12295