Human stem cell-derived hepatocytes: breakthrough of an expedient tool for preclinical assessment of drug-induced liver injury?

New developments coming from the rapidly advancing human stem cell research field are in the pipeline. In fact, due to the biological exibility of stem cells, biologists and toxicologists strongly believe that once the in vivo mechanisms driving cell differentiation and dedifferentiation are fully u...

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Bibliographic Details
Published in:Archives of toxicology 2014-02, Vol.88 (2), p.183-184
Main Authors: M. Rodrigues, Robim, De Kock, Joery
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cells, Cultured
Chemical and Drug Induced Liver Injury
Drug Evaluation, Preclinical - methods
Drug therapy
Environmental Health
Guest Editorial
Hepatocytes - drug effects
Hepatology
Humans
Injuries
Liver diseases
Occupational Medicine/Industrial Medicine
Pharmacology/Toxicology
Stem cells
Stem Cells - cytology
Toxicity Tests - methods
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Summary:New developments coming from the rapidly advancing human stem cell research field are in the pipeline. In fact, due to the biological exibility of stem cells, biologists and toxicologists strongly believe that once the in vivo mechanisms driving cell differentiation and dedifferentiation are fully understood, stem cells can be modulated la carte. As a consequence, these cells will obtain the appropriate functionalities that are required for evaluating a particular toxicological mode of action (MoA). As such, stem cells could represent a valuable t for purpose tool in the unraveling of the MoA of a chemical substance at the molecular level.
ISSN:0340-5761
1432-0738
DOI:10.1007/s00204-014-1199-5