Recognition of adverse drug events in older hospitalized medical patients

Objective To assess medical teams’ ability to recognize adverse drug events (ADEs) in older inpatients. Methods The study cohort comprised 250 patients aged 65 years or older consecutively admitted to Internal Medicine wards of three hospitals in the Netherlands between April and November 2007. An i...

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Bibliographic Details
Published in:European journal of clinical pharmacology 2013, Vol.69 (1), p.75-85
Main Authors: Klopotowska, Joanna E., Wierenga, Peter C., Smorenburg, Susanne M., Stuijt, Clementine C. M., Arisz, Lambertus, Kuks, Paul F. M., Dijkgraaf, Marcel G. W., Lie-A-Huen, Loraine, de Rooij, Sophia E.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biomedical and Life Sciences
Biomedicine
Cohort Studies
Drug therapy
Drug-Related Side Effects and Adverse Reactions - epidemiology
Female
Health Knowledge, Attitudes, Practice
Hospitalization - statistics & numerical data
Humans
Male
Netherlands - epidemiology
Older people
Patient Care Team
Pharmacoepidemiology and Prescription
Pharmacology
Pharmacology/Toxicology
Polypharmacy
Side effects
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Summary:Objective To assess medical teams’ ability to recognize adverse drug events (ADEs) in older inpatients. Methods The study cohort comprised 250 patients aged 65 years or older consecutively admitted to Internal Medicine wards of three hospitals in the Netherlands between April and November 2007. An independent expert team identified ADEs present upon admission or occurring during hospitalization by a structured retrospective patient chart review. For all ADEs identified, the expert team assessed causality, severity, preventability, and recognition by medical teams. Results The medical teams did not recognize 19.9 % of all ADEs present upon admission {60.4 ADEs [95 % confidence interval (CI) 51.5–70.8] per 100 hospitalizations} and 20.3 % of all ADEs occurring during the hospital stay [47.2 ADEs (95 % CI 39.4–56.5) per 100 hospitalizations]. Unrecognized ADEs were significantly more often ADEs with possible causality (p=0.014, df=1), ADEs caused by medication errors (p
ISSN:0031-6970
1432-1041
DOI:10.1007/s00228-012-1316-4