Copper-induced change in the ESR signal of hemoglobin nitrosyl complexes in wound by the action of copper nanoparticles

The results concerning changes in the ESR signal of hemoglobin nitrosyl complexes in wound tissues in the course of healing by the action of ointments with copper nanoparticles (patent N2460532, Russia) are presented. It is shown that the wound healing process modified by the influence of copper nan...

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Bibliographic Details
Published in:Biophysics (Oxford) 2013-09, Vol.58 (5), p.693-698
Main Authors: Volodina, L. A., Bayder, L. M., Rakhmetova, A. A., Bogoslovskaja, O. A., Olkhovskaya, I. P., Gluschenko, N. N.
Format: Article
Language:English
Subjects:
Biological and Medical Physics
Biophysics
Complex Systems Biophysics
Copper
Hemoglobin
Nanoparticles
Physics
Physics and Astronomy
Signal transduction
Wound healing
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Summary:The results concerning changes in the ESR signal of hemoglobin nitrosyl complexes in wound tissues in the course of healing by the action of ointments with copper nanoparticles (patent N2460532, Russia) are presented. It is shown that the wound healing process modified by the influence of copper nanoparticles demonstrates the increase in the ESR signal amplitude for hemoglobin nitrosyl complexes as compared with controls (the ointment base without nanoparticles). Planimetric measurements of wound area through reparation course indicate an active process of wound healing for injuries treated with copper nanoparticles in the ointment, resulting in lessening half-reparation time up to 5.0 times as compared with controls (treatment with the ointment base). The paper discusses the role of copper nanoparticles, NO and their potential synergistic effect on the skin wound regeneration.
ISSN:0006-3509
1555-6654
DOI:10.1134/S0006350913050175