Meta-Review of Protein Network Regulating Obesity Between Validated Obesity Candidate Genes in the White Adipose Tissue of High-Fat Diet-Induced Obese C57BL/6J Mice

• Published in: Critical reviews in food science and nutrition 2014-01, Vol.54 (7), p.910-923
• Main Authors: Kim, Eunjung, Kim, Eun Jung, Seo, Seung-Won, Hur, Cheol-Goo, McGregor, Robin A, Choi, Myung-Sook
• Format: Article
• Language: English
• Subjects: Adipokines - physiology; adipose tissue; Adipose Tissue, White - chemistry; Adipose Tissue, White - metabolism; Adipose tissues; Animals; Biological and medical sciences; C57BL/6J mouse; comorbidity; data collection; Diet, High-Fat; Energy Metabolism - genetics; Feeding. Feeding behavior; food science; Foods; Fundamental and applied biological sciences. Psychology; Genes; high-fat; inflammation; Inflammation - genetics; lipid metabolism; Lipid Metabolism - genetics; Lipids; Medical sciences; Metabolic diseases; Metabolism; Mice; Mice, Inbred C57BL; microarray technology; Network analysis; Networks; Nutrigenomics; nutrition science; Obesity; Obesity - etiology; Obesity - genetics; Oxidative Stress - genetics; PPAR gamma - genetics; PPAR gamma - physiology; Protein Array Analysis; protein-protein interactions; Proteins; Receptors; Target recognition; Tissues; Vertebrates: anatomy and physiology, studies on body, several organs or systems; white adipose tissue
• ISSN: 1549-7852; 1040-8398; 1549-7852
• DOI: 10.1080/10408398.2011.619283

Worldwide obesity and related comorbidities are increasing, but identifying new therapeutic targets remains a challenge. A plethora of microarray studies in diet-induced obesity models has provided large datasets of obesity associated genes. In this review, we describe an approach to examine the underlying molecular network regulating obesity, and we discuss interactions between obesity candidate genes. We conducted network analysis on functional protein–protein interactions associated with 25 obesity candidate genes identified in a literature-driven approach based on published microarray studies of diet-induced obesity. The obesity candidate genes were closely associated with lipid metabolism and inflammation. Peroxisome proliferator activated receptor gamma (Pparg) appeared to be a core obesity gene, and obesity candidate genes were highly interconnected, suggesting a coordinately regulated molecular network in adipose tissue. In conclusion, the current network analysis approach may help elucidate the underlying molecular network regulating obesity and identify anti-obesity targets for therapeutic intervention.