To Think or Not to Think: Synaptic Activity and A[beta] Release

Accumulation of β-amyloid protein (Aβ) in the extracellular space of the brain has been hypothesized to be a culprit in the pathogenesis of Alzheimer's disease. In this issue ofNeuron, Cirrito et al. describe a series of experiments demonstrating that extracellular Aβ levels are directly modula...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2005-12, Vol.48 (6), p.873
Main Authors: Schroeder, Brock E, Koo, Edward H
Format: Article
Language:English
Subjects:
Alzheimer's disease
Apoptosis
Brain
Brain research
Pathogenesis
Proteins
Rodents
Online Access:Get full text
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Summary:Accumulation of β-amyloid protein (Aβ) in the extracellular space of the brain has been hypothesized to be a culprit in the pathogenesis of Alzheimer's disease. In this issue ofNeuron, Cirrito et al. describe a series of experiments demonstrating that extracellular Aβ levels are directly modulated by neuronal and synaptic activity.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2005.12.005