To Think or Not to Think: Synaptic Activity and A[beta] Release

Accumulation of β-amyloid protein (Aβ) in the extracellular space of the brain has been hypothesized to be a culprit in the pathogenesis of Alzheimer's disease. In this issue ofNeuron, Cirrito et al. describe a series of experiments demonstrating that extracellular Aβ levels are directly modula...

Full description

Saved in:
Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2005-12, Vol.48 (6), p.873
Main Authors: Schroeder, Brock E, Koo, Edward H
Format: Article
Language:English
Subjects:
Alzheimer's disease
Apoptosis
Brain
Brain research
Pathogenesis
Proteins
Rodents
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page
container_issue 6
container_start_page 873
container_title Neuron (Cambridge, Mass.)
container_volume 48
creator Schroeder, Brock E
Koo, Edward H
description Accumulation of β-amyloid protein (Aβ) in the extracellular space of the brain has been hypothesized to be a culprit in the pathogenesis of Alzheimer's disease. In this issue ofNeuron, Cirrito et al. describe a series of experiments demonstrating that extracellular Aβ levels are directly modulated by neuronal and synaptic activity.
doi_str_mv 10.1016/j.neuron.2005.12.005
format article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_1503655573</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3234663901</sourcerecordid><originalsourceid>FETCH-proquest_journals_15036555733</originalsourceid><addsrcrecordid>eNqNirsKwjAUQIMoWB9_4HDBufHe1rTGRUQUJwftJlKiRmyVRJtU8O918AOcDodzGBsQckJKRiU3uq6s4RGi4BTxLxosIJRpOCYpmyzAiUzCJErjNus4VyLSWEgK2CyzkF0LcwNbwcZ68D-fwu5t1MMXJ5iffPEq_BuUOcN8f9ReHWCr71o53WOti7o73f-xy4arZbZYh4_KPmvtfF7aujLflJPAOBFCpHH83_UBIX0_0g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1503655573</pqid></control><display><type>article</type><title>To Think or Not to Think: Synaptic Activity and A[beta] Release</title><source>BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS</source><creator>Schroeder, Brock E ; Koo, Edward H</creator><creatorcontrib>Schroeder, Brock E ; Koo, Edward H</creatorcontrib><description>Accumulation of β-amyloid protein (Aβ) in the extracellular space of the brain has been hypothesized to be a culprit in the pathogenesis of Alzheimer's disease. In this issue ofNeuron, Cirrito et al. describe a series of experiments demonstrating that extracellular Aβ levels are directly modulated by neuronal and synaptic activity.</description><identifier>ISSN: 0896-6273</identifier><identifier>EISSN: 1097-4199</identifier><identifier>DOI: 10.1016/j.neuron.2005.12.005</identifier><language>eng</language><publisher>Cambridge: Elsevier Limited</publisher><subject>Alzheimer's disease ; Apoptosis ; Brain ; Brain research ; Pathogenesis ; Proteins ; Rodents</subject><ispartof>Neuron (Cambridge, Mass.), 2005-12, Vol.48 (6), p.873</ispartof><rights>Copyright Elsevier Limited Dec 22, 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Schroeder, Brock E</creatorcontrib><creatorcontrib>Koo, Edward H</creatorcontrib><title>To Think or Not to Think: Synaptic Activity and A[beta] Release</title><title>Neuron (Cambridge, Mass.)</title><description>Accumulation of β-amyloid protein (Aβ) in the extracellular space of the brain has been hypothesized to be a culprit in the pathogenesis of Alzheimer's disease. In this issue ofNeuron, Cirrito et al. describe a series of experiments demonstrating that extracellular Aβ levels are directly modulated by neuronal and synaptic activity.</description><subject>Alzheimer's disease</subject><subject>Apoptosis</subject><subject>Brain</subject><subject>Brain research</subject><subject>Pathogenesis</subject><subject>Proteins</subject><subject>Rodents</subject><issn>0896-6273</issn><issn>1097-4199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqNirsKwjAUQIMoWB9_4HDBufHe1rTGRUQUJwftJlKiRmyVRJtU8O918AOcDodzGBsQckJKRiU3uq6s4RGi4BTxLxosIJRpOCYpmyzAiUzCJErjNus4VyLSWEgK2CyzkF0LcwNbwcZ68D-fwu5t1MMXJ5iffPEq_BuUOcN8f9ReHWCr71o53WOti7o73f-xy4arZbZYh4_KPmvtfF7aujLflJPAOBFCpHH83_UBIX0_0g</recordid><startdate>20051222</startdate><enddate>20051222</enddate><creator>Schroeder, Brock E</creator><creator>Koo, Edward H</creator><general>Elsevier Limited</general><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20051222</creationdate><title>To Think or Not to Think: Synaptic Activity and A[beta] Release</title><author>Schroeder, Brock E ; Koo, Edward H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_15036555733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Alzheimer's disease</topic><topic>Apoptosis</topic><topic>Brain</topic><topic>Brain research</topic><topic>Pathogenesis</topic><topic>Proteins</topic><topic>Rodents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schroeder, Brock E</creatorcontrib><creatorcontrib>Koo, Edward H</creatorcontrib><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Neuron (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schroeder, Brock E</au><au>Koo, Edward H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>To Think or Not to Think: Synaptic Activity and A[beta] Release</atitle><jtitle>Neuron (Cambridge, Mass.)</jtitle><date>2005-12-22</date><risdate>2005</risdate><volume>48</volume><issue>6</issue><spage>873</spage><pages>873-</pages><issn>0896-6273</issn><eissn>1097-4199</eissn><abstract>Accumulation of β-amyloid protein (Aβ) in the extracellular space of the brain has been hypothesized to be a culprit in the pathogenesis of Alzheimer's disease. In this issue ofNeuron, Cirrito et al. describe a series of experiments demonstrating that extracellular Aβ levels are directly modulated by neuronal and synaptic activity.</abstract><cop>Cambridge</cop><pub>Elsevier Limited</pub><doi>10.1016/j.neuron.2005.12.005</doi></addata></record>
fulltext fulltext
identifier ISSN: 0896-6273
ispartof Neuron (Cambridge, Mass.), 2005-12, Vol.48 (6), p.873
issn 0896-6273
1097-4199
language eng
recordid cdi_proquest_journals_1503655573
source BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS
subjects Alzheimer's disease
Apoptosis
Brain
Brain research
Pathogenesis
Proteins
Rodents
title To Think or Not to Think: Synaptic Activity and A[beta] Release
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T18%3A10%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=To%20Think%20or%20Not%20to%20Think:%20Synaptic%20Activity%20and%20A%5Bbeta%5D%20Release&rft.jtitle=Neuron%20(Cambridge,%20Mass.)&rft.au=Schroeder,%20Brock%20E&rft.date=2005-12-22&rft.volume=48&rft.issue=6&rft.spage=873&rft.pages=873-&rft.issn=0896-6273&rft.eissn=1097-4199&rft_id=info:doi/10.1016/j.neuron.2005.12.005&rft_dat=%3Cproquest%3E3234663901%3C/proquest%3E%3Cgrp_id%3Ecdi_FETCH-proquest_journals_15036555733%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1503655573&rft_id=info:pmid/&rfr_iscdi=true