Pathway Interactions and Synaptic Plasticity in the Dendritic Tuft Regions of CA1 Pyramidal Neurons

Input comparison is thought to occur in many neuronal circuits, including the hippocampus, where functionally important interactions between the Schaffer collateral and perforant pathways have been hypothesized. We investigated this idea using multisite, whole-cell recordings and Ca 2+ imaging and f...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2009-04, Vol.62 (1), p.102-111
Main Authors: Takahashi, Hiroto, Magee, Jeffrey C.
Format: Article
Language:English
Subjects:
Anesthetics, Local - pharmacology
Animals
Animals, Newborn
Biophysics
Brain
Calcium - metabolism
Calcium Channel Blockers - pharmacology
CELLBIO
Dendrites - physiology
Electric Stimulation
Excitatory Amino Acid Antagonists - pharmacology
Experiments
Hippocampus - cytology
In Vitro Techniques
Inhibitory Postsynaptic Potentials - drug effects
Long-Term Potentiation - drug effects
Long-Term Potentiation - physiology
Membrane Potentials - drug effects
Membrane Potentials - physiology
MOLNEURO
Neural Pathways - cytology
Neural Pathways - physiology
Neuronal Plasticity - physiology
Neurons
Patch-Clamp Techniques - methods
Pyramidal Cells - cytology
Pyramidal Cells - physiology
Rats
Rats, Sprague-Dawley
Spider Venoms - pharmacology
Synapses - physiology
Tetrodotoxin - pharmacology
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Summary:Input comparison is thought to occur in many neuronal circuits, including the hippocampus, where functionally important interactions between the Schaffer collateral and perforant pathways have been hypothesized. We investigated this idea using multisite, whole-cell recordings and Ca 2+ imaging and found that properly timed, repetitive stimulation of both pathways results in the generation of large plateau potentials in distal dendrites of CA1 pyramidal neurons. These dendritic plateau potentials produce widespread Ca 2+ influx, large after-depolarizations, burst firing output, and long-term potentiation of perforant path synapses. Plateau duration is directly related to the strength and temporal overlap of pathway activation and involves back-propagating action potentials and both NMDA receptors and voltage-gated Ca 2+ channels. Thus, the occurrence of highly correlated SC and PP input to CA1 is signaled by a dramatic change in output mode and an increase in input efficacy, all induced by a large plateau potential in the distal dendrites of CA1 pyramidal neurons.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2009.03.007