Mass spectrometry analysis of blood low-molecular fraction as a method for unification of therapeutic drug monitoring

The review describes a new method of therapeutic drug monitoring (TDM) based on direct infusion of low-molecular fraction of blood into an electrospray ionization source of mass spectrometer. This technique allows performing TDM of almost all drugs used in clinical practice. Universality and a high-...

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Bibliographic Details
Published in:Biochemistry (Moscow). Supplement. Series B, Biomedical chemistry Biomedical chemistry, 2014, Vol.8 (1), p.1-10
Main Authors: Lokhov, P. G., Maslov, D. L., Trifonova, O. P., Balashova, E. E., Archakov, A. I.
Format: Article
Language:English
Subjects:
Biochemistry
Bioorganic Chemistry
Chemistry
Chemistry and Materials Science
Drug therapy
Mass spectrometry
Medicinal Chemistry
Pharmacology
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Summary:The review describes a new method of therapeutic drug monitoring (TDM) based on direct infusion of low-molecular fraction of blood into an electrospray ionization source of mass spectrometer. This technique allows performing TDM of almost all drugs used in clinical practice. Universality and a high-throughput mode of the method significantly simplify wide application of this method. Moreover, the possibility of method application in most cases of drug therapy has been argued as a tool for control of drug doses, rationality of drug therapy, and quality of drugs used. In conclusion, prospects for application of the method as primary means of improving the quality and personalization of drug therapy have been discussed.
ISSN:1990-7508
1990-7516
DOI:10.1134/S1990750814010119