The study of the neuroprotective activity of the apolipoprotein E peptide mimetic Cog1410 in transgenic strains of Drosophila melanogaster

The neuroprotective activity of peptide mimetic of apolipoprotein E (apoE) Cog1410, containing the amino acid sequence of the apoE receptor-binding domain, has been investigated in transgenic Drosophila melanogaster strains expressing human APP and beta-secretase genes. Expression of double transgen...

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Bibliographic Details
Published in:Biochemistry (Moscow). Supplement. Series B, Biomedical chemistry Biomedical chemistry, 2014, Vol.8 (1), p.37-42
Main Authors: Latypova, E. M., Timoshenko, S. I., Kislik, G. A., Vitek, M. P., Schwarzman, A. L., Sarantseva, S. V.
Format: Article
Language:English
Subjects:
Alzheimer's disease
Apolipoproteins
Biochemistry
Bioorganic Chemistry
Chemistry
Chemistry and Materials Science
Gene expression
Insects
Medicinal Chemistry
Peptides
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Summary:The neuroprotective activity of peptide mimetic of apolipoprotein E (apoE) Cog1410, containing the amino acid sequence of the apoE receptor-binding domain, has been investigated in transgenic Drosophila melanogaster strains expressing human APP and beta-secretase genes. Expression of double transgenes caused neuropathological processes typical for Alzheimer’s disease (AD): neurodegeneration, cognitive impairments, and amyloid deposition in the brain. It was shown that Cog1410 reduces neurodegeneration in the brain of transgenic flies and improves cognitive functions (odor recognition). These data suggest that Cog1410 is a potential neuroprotector that can be used in AD treatment.
ISSN:1990-7508
1990-7516
DOI:10.1134/S1990750814010107