Angioedema and estrogen-dependent angioedema with activation of the contact system

C1-INH levels remained normal when tested by means of nephelometry. Because the patients showed no sign of C1-INH deficiency in the normal state, it can be assumed that contact system activation is the primary pathogenic event in their angioedema attacks (Fig 2). The worsening effect of estrogens on...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2009, Vol.123 (1), p.262-264
Main Authors: Hentges, François, MD, Hilger, Christiane, PhD, Kohnen, Marianne, BSc, Gilson, Georges, PhD
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Angioedema
Angioedema - blood
Angioedema - chemically induced
Birth control
Complement System Proteins - analysis
Contraceptives, Oral, Hormonal - administration & dosage
Contraceptives, Oral, Hormonal - adverse effects
Estrogens
Estrogens - administration & dosage
Estrogens - adverse effects
Female
Humans
Molecular weight
Mutation
Patients
Plasma
Pregnancy
Women
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Summary:C1-INH levels remained normal when tested by means of nephelometry. Because the patients showed no sign of C1-INH deficiency in the normal state, it can be assumed that contact system activation is the primary pathogenic event in their angioedema attacks (Fig 2). The worsening effect of estrogens on hereditary angioedema has been described by several authors.2-4 In women taking oral contraception, there is an increase in Factor XII, prekallikrein, and HMWK values and a decrease in C1-INH levels.9 Because these known estrogen-related effects are insufficient to explain contact system activation and angioedema attacks in these women, other genetic or nongenetic factors that played a triggering role remain to be investigated.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2008.10.056