Advanced glycation end products contribute to the immunogenicity of IFN-[beta] pharmaceuticals

Protein-derived AGEs are formed in both eukaryotic and prokaryotic cells. [...]we hypothesized that human IFN-β produced in either Chinese hamster ovary cells (IFN-β1a) or E coli (IFN-β1b) will accumulate AGEs. [...]experimental data support involvement of both innate6 and adaptive7 immune reacti...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2012-03, Vol.129 (3), p.855
Main Authors: Bozhinov, Angelina, Handzhiyski, Yordan, Genov, Krasimir, Daskalovska, Vera, Niwa, Toshimitsu, Ivan ov, Ivan, Mironova, Roumyana
Format: Article
Language:English
Subjects:
Age
E coli
Multiple sclerosis
Patients
Pharmaceuticals
Proteins
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Summary:Protein-derived AGEs are formed in both eukaryotic and prokaryotic cells. [...]we hypothesized that human IFN-β produced in either Chinese hamster ovary cells (IFN-β1a) or E coli (IFN-β1b) will accumulate AGEs. [...]experimental data support involvement of both innate6 and adaptive7 immune reactions against AGEs.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2011.10.035