Elevated Intestinal Interleukin-13 Promotes Intestinal Epithelial Barrier Dysfunction

IIL-13Tg mice had increased serum IL-13 (17.580 ± 2.325 vs 10.540 ± 0.829 ng/ml, p = 0.0357), and reduced % saturation of IL-13Rα2 (14.24% ± 1.393% vs 24.36% ± 2.639%, p = 0.0148) as compared to WT mice, Notably, intestinal mast cell levels (7.683 ± 3.756 vs 4.267 ± 0.3812 mast cells/hpf) wer...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2009-02, Vol.123 (2), p.S186-S186
Main Authors: Wu, D.X, Ahrens, R.E, Groschwitz, K.R, Osterfield, H.N, Foster, P.S, Finkelman, F.D, Matthaei, K.I, Hogan, S.P
Format: Article
Language:English
Subjects:
Allergy and Immunology
Permeability
Rodents
Small intestine
Online Access:Get full text
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Summary:IIL-13Tg mice had increased serum IL-13 (17.580 ± 2.325 vs 10.540 ± 0.829 ng/ml, p = 0.0357), and reduced % saturation of IL-13Rα2 (14.24% ± 1.393% vs 24.36% ± 2.639%, p = 0.0148) as compared to WT mice, Notably, intestinal mast cell levels (7.683 ± 3.756 vs 4.267 ± 0.3812 mast cells/hpf) were comparable between groups; however iIL-13Tg mice had increased intestinal permeability (TER: 70.03 ± 4.852 vs 134.2 ± 10.64 Ω [low *] cm2, p = 0.0006)], transcellular flux of FITC-dextran (5.708 ± 1.461 vs 1.663 ± 0.565 ng/ml, p < 0.0001) and pararcellular flux of HRP (0.018 ± 0.0033 vs 0.005 ± 0.001 ng/ml, p < 0.0001).
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2008.12.704