Comparison of airway and peripheral blood T cell characteristics in severe asthma and COPD

T cells have been implicated in the immunopathology of asthma and COPD. The Dutch Hypothesis proposes that COPD and asthma share common mechanisms. We compared airway and peripheral blood T cell profiles in subjects with COPD and severe asthma. Absolute numbers and percentages of broncholalveolar la...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2004-02, Vol.113 (2), p.S186-S186
Main Authors: Ratoff, J.C., Allenby, M.I., Lethbridge, M.W., Turnbull, W., Cheung, A.C.L., Snape, T., Hayday, A.C., Corrigan, C.J., O'Connor, B.J.
Format: Article
Language:English
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Summary:T cells have been implicated in the immunopathology of asthma and COPD. The Dutch Hypothesis proposes that COPD and asthma share common mechanisms. We compared airway and peripheral blood T cell profiles in subjects with COPD and severe asthma. Absolute numbers and percentages of broncholalveolar lavage fluid (BALF) and peripheral blood cells expressing the T cell markers CD3, 4, 8, 27 and 45RA were measured in subjects (age 40-75 yrs, FEV 1/FVC
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2004.01.106