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A Chinese herbal medicine formula, FAHF-2, completely blocks anaphylaxis in a murine model of peanut allergy

Food allergy is a serious and growing health problem. We previously showed that Chinese herbal medicine formula, FAHF-1, protected peanut (PN)-allergic mice from anaphylaxis following oral PN challenge. We have now tested an improved formula, FAHF-2, containing fewer herbs. We employed a 14-week ora...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2004-02, Vol.113 (2), p.S337-S337
Main Authors: Srivastava, K.D., Kattan, J.D., Sampson, H.A., Li, X.M.
Format: Article
Language:English
Online Access:Get full text
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Summary:Food allergy is a serious and growing health problem. We previously showed that Chinese herbal medicine formula, FAHF-1, protected peanut (PN)-allergic mice from anaphylaxis following oral PN challenge. We have now tested an improved formula, FAHF-2, containing fewer herbs. We employed a 14-week oral PN sensitization and challenge protocol in C3H/HeJ mice. Oral treatment with FAHF-2 was performed twice daily for 7 weeks, commencing at week 3 or week 8. Anaphylactic reactions were assessed by evaluation of symptom scores, plasma histamine levels and body temperatures. Splenocytes of challenged mice were isolated cultured to evaluate cytokine production. Peanut-specific IgE was significantly reduced in FAHF-2-treated mice compared to the sham-treated mice in both early (3072 ± 101 vs 7017 ± 9.6 ng/ml, p
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2004.01.720