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A Chinese herbal medicine formula, FAHF-2, completely blocks anaphylaxis in a murine model of peanut allergy
Food allergy is a serious and growing health problem. We previously showed that Chinese herbal medicine formula, FAHF-1, protected peanut (PN)-allergic mice from anaphylaxis following oral PN challenge. We have now tested an improved formula, FAHF-2, containing fewer herbs. We employed a 14-week ora...
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Published in: | Journal of allergy and clinical immunology 2004-02, Vol.113 (2), p.S337-S337 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Online Access: | Get full text |
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Summary: | Food allergy is a serious and growing health problem. We previously showed that Chinese herbal medicine formula, FAHF-1, protected peanut (PN)-allergic mice from anaphylaxis following oral PN challenge. We have now tested an improved formula, FAHF-2, containing fewer herbs.
We employed a 14-week oral PN sensitization and challenge protocol in C3H/HeJ mice. Oral treatment with FAHF-2 was performed twice daily for 7 weeks, commencing at week 3 or week 8. Anaphylactic reactions were assessed by evaluation of symptom scores, plasma histamine levels and body temperatures. Splenocytes of challenged mice were isolated cultured to evaluate cytokine production.
Peanut-specific IgE was significantly reduced in FAHF-2-treated mice compared to the sham-treated mice in both early (3072 ± 101 vs 7017 ± 9.6 ng/ml, p |
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ISSN: | 0091-6749 1097-6825 |
DOI: | 10.1016/j.jaci.2004.01.720 |