A Chinese herbal medicine formula, FAHF-2, completely blocks anaphylaxis in a murine model of peanut allergy

Food allergy is a serious and growing health problem. We previously showed that Chinese herbal medicine formula, FAHF-1, protected peanut (PN)-allergic mice from anaphylaxis following oral PN challenge. We have now tested an improved formula, FAHF-2, containing fewer herbs. We employed a 14-week ora...

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Published in:Journal of allergy and clinical immunology 2004-02, Vol.113 (2), p.S337-S337
Main Authors: Srivastava, K.D., Kattan, J.D., Sampson, H.A., Li, X.M.
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description Food allergy is a serious and growing health problem. We previously showed that Chinese herbal medicine formula, FAHF-1, protected peanut (PN)-allergic mice from anaphylaxis following oral PN challenge. We have now tested an improved formula, FAHF-2, containing fewer herbs. We employed a 14-week oral PN sensitization and challenge protocol in C3H/HeJ mice. Oral treatment with FAHF-2 was performed twice daily for 7 weeks, commencing at week 3 or week 8. Anaphylactic reactions were assessed by evaluation of symptom scores, plasma histamine levels and body temperatures. Splenocytes of challenged mice were isolated cultured to evaluate cytokine production. Peanut-specific IgE was significantly reduced in FAHF-2-treated mice compared to the sham-treated mice in both early (3072 ± 101 vs 7017 ± 9.6 ng/ml, p
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We previously showed that Chinese herbal medicine formula, FAHF-1, protected peanut (PN)-allergic mice from anaphylaxis following oral PN challenge. We have now tested an improved formula, FAHF-2, containing fewer herbs. We employed a 14-week oral PN sensitization and challenge protocol in C3H/HeJ mice. Oral treatment with FAHF-2 was performed twice daily for 7 weeks, commencing at week 3 or week 8. Anaphylactic reactions were assessed by evaluation of symptom scores, plasma histamine levels and body temperatures. Splenocytes of challenged mice were isolated cultured to evaluate cytokine production. Peanut-specific IgE was significantly reduced in FAHF-2-treated mice compared to the sham-treated mice in both early (3072 ± 101 vs 7017 ± 9.6 ng/ml, p<0.001) and late treatment (2201 ± 190 vs 3224 ± 249 ng/ml, p<0.05) protocol groups. FAHF-2 completely protected mice from anaphylaxis to peanut challenge. No symptoms were seen in FAHF-2-treated mice whereas sham-treated mice had an average score of 2.7 (scale of 0-5). Consistently, body temperatures of FAHF-2 treated mice were markedly higher (37.2 vs 34.6 oC, p<0.05) and plasma histamine were significantly lower (2483 ± 191 vs 18,488 ± 2194 ng/ml, p<0.001) than sham-treated mice. PN-stimulated splenocytes from FAHF-2 treated mice showed significantly lower production of Th2 cytokines IL-4 (35.0 ± 11 vs 126.6 ± 25.8 pg/ml, p<) and IL-5 (759.0 ± 157 vs 1063.5 ± 195 pg/ml, p<0.05), but no difference in IFN-γ production. FAHF-2 completely prevented anaphylaxis in PN-allergic mice and down-regulated Th2 responses]]></description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2004.01.720</identifier><language>eng</language><publisher>St. Louis: Mosby, Inc</publisher><ispartof>Journal of allergy and clinical immunology, 2004-02, Vol.113 (2), p.S337-S337</ispartof><rights>2004</rights><rights>Copyright Elsevier Limited Feb 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Srivastava, K.D.</creatorcontrib><creatorcontrib>Kattan, J.D.</creatorcontrib><creatorcontrib>Sampson, H.A.</creatorcontrib><creatorcontrib>Li, X.M.</creatorcontrib><title>A Chinese herbal medicine formula, FAHF-2, completely blocks anaphylaxis in a murine model of peanut allergy</title><title>Journal of allergy and clinical immunology</title><description><![CDATA[Food allergy is a serious and growing health problem. We previously showed that Chinese herbal medicine formula, FAHF-1, protected peanut (PN)-allergic mice from anaphylaxis following oral PN challenge. We have now tested an improved formula, FAHF-2, containing fewer herbs. We employed a 14-week oral PN sensitization and challenge protocol in C3H/HeJ mice. Oral treatment with FAHF-2 was performed twice daily for 7 weeks, commencing at week 3 or week 8. Anaphylactic reactions were assessed by evaluation of symptom scores, plasma histamine levels and body temperatures. Splenocytes of challenged mice were isolated cultured to evaluate cytokine production. Peanut-specific IgE was significantly reduced in FAHF-2-treated mice compared to the sham-treated mice in both early (3072 ± 101 vs 7017 ± 9.6 ng/ml, p<0.001) and late treatment (2201 ± 190 vs 3224 ± 249 ng/ml, p<0.05) protocol groups. FAHF-2 completely protected mice from anaphylaxis to peanut challenge. No symptoms were seen in FAHF-2-treated mice whereas sham-treated mice had an average score of 2.7 (scale of 0-5). Consistently, body temperatures of FAHF-2 treated mice were markedly higher (37.2 vs 34.6 oC, p<0.05) and plasma histamine were significantly lower (2483 ± 191 vs 18,488 ± 2194 ng/ml, p<0.001) than sham-treated mice. PN-stimulated splenocytes from FAHF-2 treated mice showed significantly lower production of Th2 cytokines IL-4 (35.0 ± 11 vs 126.6 ± 25.8 pg/ml, p<) and IL-5 (759.0 ± 157 vs 1063.5 ± 195 pg/ml, p<0.05), but no difference in IFN-γ production. 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We previously showed that Chinese herbal medicine formula, FAHF-1, protected peanut (PN)-allergic mice from anaphylaxis following oral PN challenge. We have now tested an improved formula, FAHF-2, containing fewer herbs. We employed a 14-week oral PN sensitization and challenge protocol in C3H/HeJ mice. Oral treatment with FAHF-2 was performed twice daily for 7 weeks, commencing at week 3 or week 8. Anaphylactic reactions were assessed by evaluation of symptom scores, plasma histamine levels and body temperatures. Splenocytes of challenged mice were isolated cultured to evaluate cytokine production. Peanut-specific IgE was significantly reduced in FAHF-2-treated mice compared to the sham-treated mice in both early (3072 ± 101 vs 7017 ± 9.6 ng/ml, p<0.001) and late treatment (2201 ± 190 vs 3224 ± 249 ng/ml, p<0.05) protocol groups. FAHF-2 completely protected mice from anaphylaxis to peanut challenge. No symptoms were seen in FAHF-2-treated mice whereas sham-treated mice had an average score of 2.7 (scale of 0-5). Consistently, body temperatures of FAHF-2 treated mice were markedly higher (37.2 vs 34.6 oC, p<0.05) and plasma histamine were significantly lower (2483 ± 191 vs 18,488 ± 2194 ng/ml, p<0.001) than sham-treated mice. PN-stimulated splenocytes from FAHF-2 treated mice showed significantly lower production of Th2 cytokines IL-4 (35.0 ± 11 vs 126.6 ± 25.8 pg/ml, p<) and IL-5 (759.0 ± 157 vs 1063.5 ± 195 pg/ml, p<0.05), but no difference in IFN-γ production. FAHF-2 completely prevented anaphylaxis in PN-allergic mice and down-regulated Th2 responses]]></abstract><cop>St. Louis</cop><pub>Mosby, Inc</pub><doi>10.1016/j.jaci.2004.01.720</doi></addata></record>
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