A Modified Adenine Chemically Coupled to Allergenic Molecule(s) as Inducer of Allergen-specific Th2 Cells Redirection

The 8-OH-substituted adenine SA-26E chemically coupled with Dermatophagoides pteronyssinus extract (DP-Conj) or purified natural Der p2 (nDer-Conj) was evaluated for induction of NF-kB in CD14+ cells, cytokine production in BDCA4+ and CD14+ cells, Th-skewing effects in allergen-specific human T cell...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2010-02, Vol.125 (2), p.AB131-AB131
Main Authors: Filì, L, Cardilicchia, E, Casini, A, Maggi, L, Manuelli, C, Fassio, F, Matucci, A, Vultaggio, A, Annunziato, F, Occhiato, E, Maggi, E, Romagnani, S, Parronchi, P
Format: Article
Language:English
Subjects:
Allergy and Immunology
Cytokines
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Summary:The 8-OH-substituted adenine SA-26E chemically coupled with Dermatophagoides pteronyssinus extract (DP-Conj) or purified natural Der p2 (nDer-Conj) was evaluated for induction of NF-kB in CD14+ cells, cytokine production in BDCA4+ and CD14+ cells, Th-skewing effects in allergen-specific human T cell lines, TLR-triggering in transfected HEK293 cell line.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2009.12.516