Human Papillomavirus (HPV)-Specific T-cells Recognizing Dominant E2/E6 Epitopes Elicit Reduced IFN-[gamma] in Patients with Recurrent Respiratory Papillomatosis (RRP)

[...]RPP patients exhibit HPV-specific, immune dysregulation, indicated by a lack of IFN-γ secretion. [...]therapeutic vaccination or other interventions that repolarize T-cell responses and restore TH1-like cytokine responses to HPV proteins could improve outcomes for RPP patients.

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2010-02, Vol.125 (2), p.AB77
Main Authors: James, E, DeVoti, JA, Rosenthal, DW, Hatam, LJ, Steinberg, BM, Abramson, A, Kwok, WW, Bonagura, VR
Format: Article
Language:English
Subjects:
Cytokines
Haplotypes
Human papillomavirus
Peptides
Proteins
Online Access:Get full text
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Description
Summary:[...]RPP patients exhibit HPV-specific, immune dysregulation, indicated by a lack of IFN-γ secretion. [...]therapeutic vaccination or other interventions that repolarize T-cell responses and restore TH1-like cytokine responses to HPV proteins could improve outcomes for RPP patients.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2009.12.303