Immune Regulation by CD4+CD25+ regulatory T cells in Patients with Japanese Cedar Pollinosis

The production of IFN-γ, but not that of IL-5 was significantly enhanced in CD4+CD25- cell cultures compared to that in CD4+ cell cultures. [...]in specimens from patients showing enhanced immune responses, the addition of anti-GITR to cocultures of PBMC with allergen increased the production of Th...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2010-02, Vol.125 (2), p.AB144-AB144
Main Authors: Yamanishi, T, Chikamatsu, K, Takahashi, G, Endo, S, Masuyama, K
Format: Article
Language:English
Subjects:
Allergy and Immunology
Lymphocytes
Medical research
Online Access:Get full text
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Summary:The production of IFN-γ, but not that of IL-5 was significantly enhanced in CD4+CD25- cell cultures compared to that in CD4+ cell cultures. [...]in specimens from patients showing enhanced immune responses, the addition of anti-GITR to cocultures of PBMC with allergen increased the production of Th1 or Th2 cytokine.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2009.12.566