Surfactant Protein D (SP-D) Binds to Signal Regulatory Protein Alpha (SIRP-α) on Alveolar Macrophages and Dendritic Cells and Promotes Allergen-Induced Lymph-Node Directed Migration

Fluorescently labeled lung dendritic cells failed to migrate into the mediastinal lymph nodes after inhalation of allergen in SP-D-/- mice that were also unable to upregulate lung mRNA for Ccr7, a chemokine receptor, responsible for immune cell lymph-node homing.

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2010-02, Vol.125 (2), p.AB126-AB126
Main Authors: Forbes, L.R, Ducka, B, Fehrenbach, M, Hortobagyi, L, Zhu, X, Kierstein, S, Sharma, S.K, Haczku, A
Format: Article
Language:English
Subjects:
Allergy and Immunology
Gene expression
Immune system
Medical research
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Description
Summary:Fluorescently labeled lung dendritic cells failed to migrate into the mediastinal lymph nodes after inhalation of allergen in SP-D-/- mice that were also unable to upregulate lung mRNA for Ccr7, a chemokine receptor, responsible for immune cell lymph-node homing.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2009.12.498