The Effects Of An H3 Receptor Antagonist In A Nasal Allergen Challenge Model

RATIONALE: Since nasal H3 receptors may be important in the pathogenesis of allergic rhinitis, we explored the effect of the potent oral H3 receptor antagonist PF-03654746 on subjective (symptoms) and objective (acoustic rhinometry) responses to nasal allergen challenge.

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2010-02, Vol.125 (2), p.AB191-AB191
Main Authors: Romero, F.A, Allan, R.J, Phillips, P.G, Hutchinson, K, Misfeldt, J.M, Casale, T.B
Format: Article
Language:English
Subjects:
Allergies
Allergy and Immunology
Drug therapy
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Summary:RATIONALE: Since nasal H3 receptors may be important in the pathogenesis of allergic rhinitis, we explored the effect of the potent oral H3 receptor antagonist PF-03654746 on subjective (symptoms) and objective (acoustic rhinometry) responses to nasal allergen challenge.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2009.12.750