Evaluation of IgG Trough Level Ratios as an Aid to Dosing of Subcutaneous IgG

In recent US studies, the SCIG dose was adjusted so the area under the curve (AUC) of serum IgG vs time would equal that with IVIG. Since SCIG gives near-constant IgG levels, we determined whether ratios of the trough levels on SCIG versus IVIG confirm equivalence of the AUCs.

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2010-02, Vol.125 (2), p.AB139-AB139
Main Authors: Rojavin, M, Zenker, O, Kiessling, P, Berger, M
Format: Article
Language:English
Subjects:
Allergy and Immunology
Breath tests
Online Access:Get full text
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Description
Summary:In recent US studies, the SCIG dose was adjusted so the area under the curve (AUC) of serum IgG vs time would equal that with IVIG. Since SCIG gives near-constant IgG levels, we determined whether ratios of the trough levels on SCIG versus IVIG confirm equivalence of the AUCs.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2009.12.547