T-Cell Activation Mediated by Facilitated Antigen Presentation (FAP) Is Directly Affected by Individual IgE Antibody Affinity

Rationale The formation of complexes between IgE, allergen and cell-surface expressed IgE-binding receptors Fc[varepsilon]RI and CD23 is the basis for the immediate allergic reaction from mast-cells/basophils and for the activation of allergen-specific T-cells through facilitated antigen presentatio...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2008-02, Vol.121 (2), p.S116-S116
Main Authors: Willumsen, N, Wurtzen, P.A, Holm, J, Christensen, L.H, Lund, K
Format: Article
Language:English
Subjects:
Allergies
Allergy and Immunology
T cell receptors
Online Access:Get full text
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Summary:Rationale The formation of complexes between IgE, allergen and cell-surface expressed IgE-binding receptors Fc[varepsilon]RI and CD23 is the basis for the immediate allergic reaction from mast-cells/basophils and for the activation of allergen-specific T-cells through facilitated antigen presentation (FAP).
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2007.12.461