Hypoxia inducible factor 1-[alpha] expression as a factor predictive of efficacy of taxane/platinum chemotherapy in advanced primary epithelial ovarian cancer

To investigate the impact on survival of HIF 1-α expression on primary advanced epithelial ovarian cancer (EOC), we examined the correlations between prognosis and HIF 1-α expression by Western blot analysis in 52 cases of stage III/IV EOC. HIF 1-α expression was confirmed in 36 cases (69.2%) of EOC...

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Bibliographic Details
Published in:Cancer letters 2007-06, Vol.251 (1), p.164
Main Authors: Nakai, Hidekatsu, Watanabe, Yoh, Ueda, Haruhiko, Hoshiai, Hiroshi
Format: Article
Language:English
Subjects:
Chemotherapy
Clinical trials
Hypoxia
Medical prognosis
Ovarian cancer
Proteins
Response rates
Surgery
Tumors
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Summary:To investigate the impact on survival of HIF 1-α expression on primary advanced epithelial ovarian cancer (EOC), we examined the correlations between prognosis and HIF 1-α expression by Western blot analysis in 52 cases of stage III/IV EOC. HIF 1-α expression was confirmed in 36 cases (69.2%) of EOC, and HIF 1-α-expressing tumors had a significantly higher rate of response (p
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2006.11.017