Diphenylmethyl selenocyanate inhibits DMBA–croton oil induced two-stage mouse skin carcinogenesis by inducing apoptosis and inhibiting cutaneous cell proliferation

• Published in: Cancer letters 2005-12, Vol.230 (1), p.90-101
• Main Authors: Das, Rajat Kumar, Hossain, S.K. Ugir, Bhattacharya, Sudin
• Format: Article
• Language: English
• Subjects: 9,10-Dimethyl-1,2-benzanthracene - toxicity; Animals; Apoptosis; Apoptosis - drug effects; Cancer; Carcinogens - toxicity; Caspase 3; Caspases - analysis; Caspases - biosynthesis; Cell growth; Cell proliferation; Cell Proliferation - drug effects; Chemoprevention; Croton Oil - toxicity; Dermatologic Agents - toxicity; Diphenylmethyl selenocyanate; Drug dosages; Experiments; Female; Mice; Organoselenium Compounds - pharmacology; Papilloma - chemically induced; Papilloma - physiopathology; Papilloma - prevention & control; Rodents; Selenium; Skin; Skin Neoplasms - chemically induced; Skin Neoplasms - physiopathology; Skin Neoplasms - prevention & control; Two-stage skin carcinogenesis
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2004.12.021

Numerous epidemiological and experimental studies have showed the inverse relationship between dietary selenium intake and different types of cancer. Continuous efforts are going on to develop suitable organoselenium compounds, which can be used as cancer chemopreventive agents for human. In the present study, a synthetic organoselenium compound diphenylmethyl selenocyanate was evaluated for its ability to arrest cell proliferation and to induce apoptosis against 7,12-dimethylbenz[a]anthracene–croton oil induced two-stage mouse skin carcinogenesis model. Reduction in the incidence and number of papilloma, the preneoplastic lesion, was considered to be the mean of assessment. Significant decrease in the level of cell proliferation ( p