Molecular pathways in malignant pleural mesothelioma

Malignant pleural mesothelioma, although uncommon, is highly lethal. There is a high correlation between associated environmental exposure factors, carcinogens, and its development. Carcinogenesis is also mediated by genetic defects that result in loss of tumor suppressors or over expression of prot...

Full description

Saved in:
Bibliographic Details
Published in:Cancer letters 2006-08, Vol.239 (2), p.183-189
Main Authors: Whitson, Bryan A., Kratzke, Robert A.
Format: Article
Language:English
Subjects:
Asbestos
CDK inhibitor
Cell culture
Cell Transformation, Neoplastic - genetics
Genes
Genotype & phenotype
Humans
IGF
Insulin-like growth factors
Kinases
Medical prognosis
Mesothelioma
Mesothelioma - genetics
Mutation
Phosphorylation
Pleural Neoplasms - genetics
Proteins
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Malignant pleural mesothelioma, although uncommon, is highly lethal. There is a high correlation between associated environmental exposure factors, carcinogens, and its development. Carcinogenesis is also mediated by genetic defects that result in loss of tumor suppressors or over expression of proto-oncogenes. Factors such as the loss of CDK inhibition function, IGF stimulatory pathways, p14 ARF, p15 INK4b, p16 INK4a, p21, and p53 loss or mutation, VEGF and COX over expression are discussed. Correlations to potential therapeutic modalities are made.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2005.08.010