Thymosin[alpha]1 stimulates cell proliferation by activating ERK1/2, JNK, and increasing cytokine secretion in human pancreatic cancer cells

In this study, we investigated the expression and function of thymosinα1 (Thyα1) in human pancreatic cancer. We found that human pancreatic cancer cell lines Panc-1, Panc03.27, ASPC-1, and PL45 cells significantly over-expressed the mRNA of Thyα1 as compared to the normal human pancreatic ductal epi...

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Published in:Cancer letters 2007-04, Vol.248 (1), p.58
Main Authors: Li, Min, Feurino, Louis W, Li, Fei, Wang, Hao, Zhai, Qihui, Fisher, William E, Chen, Changyi, Yao, Qizhi
Format: Article
Language:English
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Cell growth
Immune system
Kinases
Pancreas
Pancreatic cancer
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container_issue 1
container_start_page 58
container_title Cancer letters
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creator Li, Min
Feurino, Louis W
Li, Fei
Wang, Hao
Zhai, Qihui
Fisher, William E
Chen, Changyi
Yao, Qizhi
description In this study, we investigated the expression and function of thymosinα1 (Thyα1) in human pancreatic cancer. We found that human pancreatic cancer cell lines Panc-1, Panc03.27, ASPC-1, and PL45 cells significantly over-expressed the mRNA of Thyα1 as compared to the normal human pancreatic ductal epithelium (HPDE) cells.. Thyα1 mRNA and protein levels were also over-expressed in clinical pancreatic adenocarcinoma specimens. In addition, synthetic Thyα1 significantly promoted Panc-1 cell proliferation and increased phosphorylation of ERK1/2 and JNK. Furthermore, Thyα1 increased the secretion of multiple cytokines including IL-10, IL-13, and IL-17 in Panc-1 cells. Thus, Thyα1 may have a new role in pancreatic cancer pathogenesis.
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subjects Cell growth
Immune system
Kinases
Pancreas
Pancreatic cancer
title Thymosin[alpha]1 stimulates cell proliferation by activating ERK1/2, JNK, and increasing cytokine secretion in human pancreatic cancer cells
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