Peripheral T cell lymphoma in Asia

Peripheral T-cell lymphomas (PTCLs) comprise a heterogeneous group of mature T- and NK-cell neoplasms, the incidence of which is higher in Asian countries than in Western countries. Although its etiology is mainly unknown, several risk factors (such as genetic factors, abnormal immunity, environment...

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Bibliographic Details
Published in:International journal of hematology 2014-03, Vol.99 (3), p.227-239
Main Authors: Park, Sanghui, Ko, Young Hyeh
Format: Article
Language:English
Subjects:
Asia - epidemiology
Gastrointestinal Neoplasms
Hematology
Herpesvirus 4, Human
Humans
Incidence
Killer Cells, Natural - pathology
Killer Cells, Natural - virology
Lymphoma, T-Cell, Peripheral - classification
Lymphoma, T-Cell, Peripheral - epidemiology
Lymphoma, T-Cell, Peripheral - genetics
Lymphoma, T-Cell, Peripheral - pathology
Lymphoproliferative Disorders - pathology
Lymphoproliferative Disorders - virology
Medicine
Medicine & Public Health
Oncology
Progress in Hematology
Receptor Protein-Tyrosine Kinases
Risk Factors
Skin Neoplasms
T-Lymphocytes - pathology
T-Lymphocytes - virology
World Health Organization
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Summary:Peripheral T-cell lymphomas (PTCLs) comprise a heterogeneous group of mature T- and NK-cell neoplasms, the incidence of which is higher in Asian countries than in Western countries. Although its etiology is mainly unknown, several risk factors (such as genetic factors, abnormal immunity, environmental factors, and infectious causes) have been proposed. PTCL are classified based on a combination of several parameters, including morphology, site of presentation, viral status, immunophenotype, and specific genetic alterations. Their classification is ongoing, with the emergence of new entities and refinement of existing entities because of the development of diagnostic markers and new genetic alterations. This review presents epidemiologic data for PTCL in Asia, together with recent progress in the pathology of PTCL compared with the WHO 2008 classification.
ISSN:0925-5710
1865-3774
DOI:10.1007/s12185-014-1520-3