The procyanidin-mediated induction of apoptosis and cell-cycle arrest in esophageal adenocarcinoma cells is not dependent on p21Cip1/WAF1

Abstract Previous studies have shown that the proanthocyanidin-mediated induction of apoptosis and arrest of the cell cycle in cancer cells was associated with up-regulation of p21Cip1/WAF1 (p21), suggesting that p21 may be the molecular mediator of the observed effects. Here we show that procyanidi...

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Bibliographic Details
Published in:Cancer letters 2008-11, Vol.270 (2), p.234-241
Main Authors: Pierini, R, Kroon, P.A, Guyot, S, Johnson, I.T, Belshaw, N.J
Format: Article
Language:English
Subjects:
Apoptosis
Cancer
Cell adhesion & migration
Cell culture
Cell cycle
Fruits
Gene expression
Hematology, Oncology and Palliative Medicine
Medical prognosis
Proteins
Studies
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Summary:Abstract Previous studies have shown that the proanthocyanidin-mediated induction of apoptosis and arrest of the cell cycle in cancer cells was associated with up-regulation of p21Cip1/WAF1 (p21), suggesting that p21 may be the molecular mediator of the observed effects. Here we show that procyanidins induce a rapid and sustained arrest of the cell cycle, and increase apoptosis, concomitant with an increase in p21 expression. However, blocking the PA-induced up-regulation of p21 expression with siRNA did not alter PA-mediated changes in apoptosis and cell cycle, demonstrating that p21 is not responsible for the PA-induced effects.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2008.05.004