A novel gain-of-function mutation of TGF-[beta] receptor II promotes cancer progression via delayed receptor internalization in oral squamous cell carcinoma

Highlights * We present a novel gain-of-function mutation of TGF-β receptor II (TβRII) in human oral squamous cell carcinoma. * This mutation of TβRII enhances TGF-β signaling. * Mutation of TβRII induces higher migratory and invasive capabilities. * Enhanced TGF-β signaling by this mutation is due...

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Bibliographic Details
Published in:Cancer letters 2012-02, Vol.315 (2), p.161
Main Authors: Park, Iha, Son, Hwa-Kyung, Che, Zhong Min, Kim, Jin
Format: Article
Language:English
Subjects:
Cancer
Cloning
Kinases
Ligands
Lipids
Mutagenesis
Mutation
Phosphorylation
Signal transduction
Technological change
Tumors
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Summary:Highlights * We present a novel gain-of-function mutation of TGF-β receptor II (TβRII) in human oral squamous cell carcinoma. * This mutation of TβRII enhances TGF-β signaling. * Mutation of TβRII induces higher migratory and invasive capabilities. * Enhanced TGF-β signaling by this mutation is due to delayed TβRII internalization.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2011.09.036