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GCF2/LRRFIP1 promotes colorectal cancer metastasis and liver invasion through integrin-dependent RhoA activation
Highlights ► GCF2 suppression inhibits the formation of liver metastasis in mouse xenograft model. ► Suppression of GCF2 reduces cell adhesion and invasion in colorectal cancer cells. ► GCF2 regulates fibronectin-induced RhoA activity.
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Published in: | Cancer letters 2012-12, Vol.325 (1), p.99-107 |
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Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Highlights ► GCF2 suppression inhibits the formation of liver metastasis in mouse xenograft model. ► Suppression of GCF2 reduces cell adhesion and invasion in colorectal cancer cells. ► GCF2 regulates fibronectin-induced RhoA activity. |
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ISSN: | 0304-3835 1872-7980 |
DOI: | 10.1016/j.canlet.2012.06.012 |