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GCF2/LRRFIP1 promotes colorectal cancer metastasis and liver invasion through integrin-dependent RhoA activation

Highlights ► GCF2 suppression inhibits the formation of liver metastasis in mouse xenograft model. ► Suppression of GCF2 reduces cell adhesion and invasion in colorectal cancer cells. ► GCF2 regulates fibronectin-induced RhoA activity.

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Bibliographic Details
Published in:Cancer letters 2012-12, Vol.325 (1), p.99-107
Main Authors: Ariake, Kyohei, Ohtsuka, Hideo, Motoi, Fuyuhiko, Douchi, Daisuke, Oikawa, Masaya, Rikiyama, Toshiki, Fukase, Koji, Katayose, Yu, Egawa, Shinichi, Unno, Michiaki
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Language:English
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Summary:Highlights ► GCF2 suppression inhibits the formation of liver metastasis in mouse xenograft model. ► Suppression of GCF2 reduces cell adhesion and invasion in colorectal cancer cells. ► GCF2 regulates fibronectin-induced RhoA activity.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2012.06.012