Synergistic effect of panobinostat and bortezomib on chemoresistant acute myelogenous leukemia cells via AKT and NF-[kappa]B pathways

Highlights * We detected that panobinostat and bortezomib had synergistic effects on chemoresistant AML cells. * The agents in combination increased the sensitivity of HL60/ADR cells to adriamycin. * We demonstrated that the combined treatment induced apoptosis and drug metabolism. * These effects w...

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Bibliographic Details
Published in:Cancer letters 2012-12, Vol.326 (2), p.135
Main Authors: Jiang, Xue-Jie, Huang, Kai-Kai, Yang, Mo, Qiao, Liang, Wang, Qiang, Ye, Jie-Yu, Zhou, Hong-Sheng, Yi, Zheng-Shan, Wu, Fu-Qun, Wang, Zhi-Xiang, Zhao, Qing-Xia, Meng, Fan-Yi
Format: Article
Language:English
Subjects:
Apoptosis
Chemotherapy
Cytotoxicity
DNA repair
Drug resistance
Kinases
Lymphoma
Medical prognosis
Pharmaceuticals
Phosphorylation
Proteins
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Summary:Highlights * We detected that panobinostat and bortezomib had synergistic effects on chemoresistant AML cells. * The agents in combination increased the sensitivity of HL60/ADR cells to adriamycin. * We demonstrated that the combined treatment induced apoptosis and drug metabolism. * These effects were likely to be mediated via inhibition of AKT and NF-κB pathways.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2012.07.030