Triglyceride-rich lipoprotein remnant levels and metabolism: Time to adopt these orphan risk factors?Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology

The preferential excess of these very large, nonatherogenic TGRLs above a plasma TG of approximately 600 to 800 mg/dl (3) paradoxically results in generally low (4), albeit not always absent (5), atherosclerosis risk at the highest TG levels. [...]TG contrasts sharply with cholesterol, with its limi...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2004-06, Vol.43 (12), p.2233
Main Authors: Brinton, Eliot A, Nanjee, MNazeem, Hopkins, Paul N
Format: Article
Language:English
Subjects:
Atherosclerosis
Atoms & subatomic particles
Cardiology
Cardiovascular disease
Cholesterol
Diabetes
Lipids
Low density lipoprotein
Metabolism
Plasma
Risk factors
Rodents
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Summary:The preferential excess of these very large, nonatherogenic TGRLs above a plasma TG of approximately 600 to 800 mg/dl (3) paradoxically results in generally low (4), albeit not always absent (5), atherosclerosis risk at the highest TG levels. [...]TG contrasts sharply with cholesterol, with its limited metabolism, well-established involvement in atherogenesis, and relative constancy in plasma level, such that risk even from somewhat heterogeneous low-density lipoprotein (LDL) particles is a strong log-linear function (6). [...]reduced lipolysis decreases generation of free fatty acids, which are natural activator ligands to alpha subclass peroxisome proliferator activated receptors (PPARs).
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2004.04.001