Phosphodiesterase-4 Activity

Atrial excitation-contraction coupling (ECC) and pacemaker activity are both dependent on intracellular calcium (Ca2+) cycling, and alterations in Ca2+ cycling are strongly implicated in the pathophysiology of atrial fibrillation (AF). Elevated cAMP levels increase protein kinase A (PKA) activity, p...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2012-06, Vol.59 (24), p.2191-2192
Main Authors: Van Wagoner, David R., PhD, Lindsay, Bruce D., MD
Format: Article
Language:English
Subjects:
Cardiology
Cardiovascular
Genomes
Heart
Heart rate
Hypotheses
Internal Medicine
Kinases
Muscular system
Sinuses
Studies
Veins & arteries
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Summary:Atrial excitation-contraction coupling (ECC) and pacemaker activity are both dependent on intracellular calcium (Ca2+) cycling, and alterations in Ca2+ cycling are strongly implicated in the pathophysiology of atrial fibrillation (AF). Elevated cAMP levels increase protein kinase A (PKA) activity, promoting the phosphorylation of the LTCC, ryanodine receptor, HCN channels, troponin I, and phospholamban. [...]during sympathetic stimulation, Ca2+ influx is enhanced, heart rate is increased, the Ca2+ transient is larger, contractile activity is increased, and reuptake of Ca2+ into the sarcoplasmic reticulum is enhanced.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2012.03.027