Atrial Autonomic Innervation

Atrial fibrillation is the most common arrhythmia and is associated with significant morbidity and mortality. The autonomic nervous system contributes to the creation of atrial fibrillation substrates. Atrial electrophysiology is influenced differently by sympathetic and parasympathetic activation....

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American College of Cardiology 2014-01, Vol.63 (3), p.215-224
Main Authors: Linz, Dominik, MD, Ukena, Christian, MD, Mahfoud, Felix, MD, Neuberger, Hans-Ruprecht, MD, PhD, Böhm, Michael, MD
Format: Article
Language:English
Subjects:
atrial fibrillation
autonomic modulation
baroreflex stimulation
Blood pressure
Cardiac arrhythmia
Cardiology
Cardiovascular
Heart
Hypertension
Hypoxia
Internal Medicine
Neural networks
renal denervation
Rodents
Spinal cord
Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Atrial fibrillation is the most common arrhythmia and is associated with significant morbidity and mortality. The autonomic nervous system contributes to the creation of atrial fibrillation substrates. Atrial electrophysiology is influenced differently by sympathetic and parasympathetic activation. Several strategies are available to modulate the complex interaction between the autonomic nervous system and the heart. However, different approaches target the problem differently making the prediction of arrhythmogenic and/or antiarrhythmic effects difficult. We discuss the role of the autonomic nervous system on the development of a substrate for atrial fibrillation and explore the potential antiarrhythmic and/or arrhythmogenic effect of modulation of the autonomic nervous system by renal sympathetic denervation, ganglionated plexi ablation, ganglion stellatum ablation, high thoracic epidural anesthesia, low-level vagal nerve stimulation, and baroreflex stimulation.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2013.09.020