Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations

The coagulation system links immediate (hemostatic) and late (inflammatory, angiogenic) tissue responses to injury, a continuum that often is subverted in cancer. Here we provide evidence that tumor dormancy is influenced by tissue factor (TF), the cancer cell-associated initiator of the coagulation...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2014-03, Vol.111 (9), p.3544-3549
Main Authors: Magnus, Nathalie, Garnier, Delphine, Meehan, Brian, McGraw, Serge, Lee, Tae Hoon, Caron, Maxime, Bourque, Guillaume, Milsom, Chloe, Jabado, Nada, Trasler, Jacquetta, Pawlinski, Rafal, Mackman, Nigel, Rak, Janusz
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Biological Sciences
Cancer
Cell growth
Cell Line, Tumor
Cell lines
Cellular biology
Coagulation
DNA Copy Number Variations
DNA Methylation
Dormancy
Gene expression
Gene Expression Profiling
Gene Expression Regulation, Neoplastic - genetics
Gene Silencing
Genomics
Glioblastoma
Glioma
Glioma - metabolism
Glioma - physiopathology
Humans
Mice
Mutation - genetics
Neoplastic Processes
Phenotypes
Statistics, Nonparametric
Thromboplastin - metabolism
Tumor cell line
Tumor Microenvironment - genetics
Tumors
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Summary:The coagulation system links immediate (hemostatic) and late (inflammatory, angiogenic) tissue responses to injury, a continuum that often is subverted in cancer. Here we provide evidence that tumor dormancy is influenced by tissue factor (TF), the cancer cell-associated initiator of the coagulation system and a signaling receptor. Thus, indolent human glioma cells deficient for TF remain viable but permanently dormant at the injection site for nearly a year, whereas the expression of TF leads to a step-wise transition to latent and overt tumor growth phases, a process that is preceded by recruitment of vascular (CD105 ⁺) and myeloid (CD11b ⁺ and F4/80 ⁺) cells. Importantly, the microenvironment orchestrated by TF expression drives permanent changes in the phenotype, gene-expression profile, DNA copy number, and DNA methylation state of the tumor cells that escape from dormancy. We postulate that procoagulant events in the tissue microenvironment (niche) may affect the fate of occult tumor cells, including their biological and genetic progression to initiate a full-blown malignancy.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1314118111