Modeling serotonin 1A receptors in baboon and human subjects using the agonist tracer [ 11C]CUMI-101 and positron emission tomography

Here we report further evaluation of in vivo modeling options for [11C]MMP, now called [11C]CUMI-101 in both baboon and human subjects, including specificity, reproducibility and ability to quantify the agonist high affinity conformation receptor subgroup. Conclusion Based on a measurable free fract...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2008, Vol.41, p.T18-T18
Main Authors: Mann, J. John, Milak, M., Kumar, J.S.D., Majo, V.J., Severance, A.J., Ogden, R.T., Prabhakaran, J., Arango, V., Parsey, R.V.
Format: Article
Language:English
Subjects:
Medical imaging
Serotonin
Online Access:Get full text
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Summary:Here we report further evaluation of in vivo modeling options for [11C]MMP, now called [11C]CUMI-101 in both baboon and human subjects, including specificity, reproducibility and ability to quantify the agonist high affinity conformation receptor subgroup. Conclusion Based on a measurable free fraction, high affinity, selectivity, blood brain permeability and favorable plasma and brain kinetics, [11C]CUMI-101 appears to be a candidate for imaging high affinity 5-HT1A receptors and could be used to assess changes in intra-synaptic levels of endogenous serotonin.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2008.04.192