Herpes simplex encephalitis in rats: A positron emission tomography study with [ 18F]-FHBG, [ 11C]- (R)-PK11195 and [ 18F]-FDG

Both the presence of active HSV-1 in the central nervous system and the accompanying activation of microglia cells can play a role in neurological diseases and we therefore used positron emission tomography to study active HSV-1 ([18F]-FHBG) and the related microglia cell activation ([11C]-(R)-PK111...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2008, Vol.41, p.T110-T110
Main Authors: Doorduin, Janine, Klein, H.C., Dierckx, R.A., deVries, E.F.J.
Format: Article
Language:English
Subjects:
Encephalitis
Immunization
Medical research
Rodents
Tomography
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Summary:Both the presence of active HSV-1 in the central nervous system and the accompanying activation of microglia cells can play a role in neurological diseases and we therefore used positron emission tomography to study active HSV-1 ([18F]-FHBG) and the related microglia cell activation ([11C]-(R)-PK11195) in the central nervous system in a rat model of herpes simplex encephalitis (HSE). [...]to the regional increased uptake of both [18F]-FHBG and [11C]-(R)-PK11195, a global increase was found in [18F]-FDG uptake, with a significantly higher (p
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2008.04.079