Lower brain serotonin transporter binding potential in unipolar acutely depressed patients — A preliminary [ 11C]DASB PET study

Regions of interest Healthy controls (n=25) Mean (SD) Acutely depressed (n=11) Mean (SD) Amygdala 1.80 (0.3) 1.85 (0.3) Anterior cingulate cortex 0.76 (0.2) 0.71 (0.3) Caudate 1.39 (0.4) 1.12 (0.7) Dorsal raphe 4.79 (1.5) 3.22 (1.9) * Frontal cortex 0.45 (0.1) 0.42 (0.2) Hippocampus 0.91 (0.2) 0.94...

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Published in:NeuroImage (Orlando, Fla.) Fla.), 2008, Vol.41, p.T167-T167
Main Authors: Selvaraj, Sudhakar, Murthy, V., Bhagwagar, Z., Bose, S.K., Cowen, P.J., Grasby, P.M.
Format: Article
Language:English
Subjects:
Antidepressants
Mental depression
Serotonin
Variance analysis
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Summary:Regions of interest Healthy controls (n=25) Mean (SD) Acutely depressed (n=11) Mean (SD) Amygdala 1.80 (0.3) 1.85 (0.3) Anterior cingulate cortex 0.76 (0.2) 0.71 (0.3) Caudate 1.39 (0.4) 1.12 (0.7) Dorsal raphe 4.79 (1.5) 3.22 (1.9) * Frontal cortex 0.45 (0.1) 0.42 (0.2) Hippocampus 0.91 (0.2) 0.94 (0.5) Insula 1.09 (0.2) 1.1 (0.3) Putamen 1.91 (0.4) 1.73 (0.5) Thalamus 1.75 (0.4) 1.36 (0.6) * Table 1 [11C]DASB 5-HTT binding potential in healthy controls and acutely depressed patients *Significant difference p
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2008.04.134