Quantification of 11C- PIB kinetics in mouse brain using metabolite- corrected arterial input function

Simultaneously with the intravenous 11C-PIB (0.4-1.8 mCi, 0.2 ml) injection, 90-minute PET data acquisition and arterial blood sampling were started. Tissue time-activity curves (tTACs) in the neocortex and cerebellum were obtained from dynamic PET data and total volume of distribution (VT) was esti...

Full description

Saved in:
Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2008, Vol.41, p.T32-T32
Main Authors: Seki, Chie, Tokunaga, M., Hattori, S., Shidahara, M., Nakao, R., Maeda, J., Toyama, H., Irie, T., Higuchi, M., Suhara, T., Kanno, I., Kimura, Y.
Format: Article
Language:English
Subjects:
Blood pressure
Plasma
Studies
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Simultaneously with the intravenous 11C-PIB (0.4-1.8 mCi, 0.2 ml) injection, 90-minute PET data acquisition and arterial blood sampling were started. Tissue time-activity curves (tTACs) in the neocortex and cerebellum were obtained from dynamic PET data and total volume of distribution (VT) was estimated with one-tissue compartment model analysis (1TCM) and graphical analysis (GA) (Logan et al., 1990).
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2008.04.206