Synthesis and in vivo PET imaging studies with [ 11C]BU4033, a potential delta opioid imaging agent

Rats were anesthetized (isoflurane), a tail vein catheter was inserted, and the animals were imaged for 1 h following bolus i.v. injection of radiotracer. Monkey brain imaging showed clear uptake and retention of radiotracer in striatum, cortex and thalamus, with low concentrations in cerebellum.

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2008, Vol.41, p.T23-T23
Main Authors: Kilbourn, Michael R., Donnelly, D., Husbands, S.M., Greedy, B., Woods, J.H., Traynor, J.R.
Format: Article
Language:English
Subjects:
Digital video recorders
Pets
Rodents
Studies
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Summary:Rats were anesthetized (isoflurane), a tail vein catheter was inserted, and the animals were imaged for 1 h following bolus i.v. injection of radiotracer. Monkey brain imaging showed clear uptake and retention of radiotracer in striatum, cortex and thalamus, with low concentrations in cerebellum.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2008.04.197