Treatment resistant depression explained? Regional increase of P- glycoprotein function in the blood- brain barrier of patients with major depression

The brain is protected against blood borne toxic influences by the blood-brain barrier, which includes the molecular efflux pump P-glycoprotein (P-gp) in the vessel wall of brain capillaries.

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2008, Vol.41, p.T35-T35
Main Authors: de Klerk, Onno L., Willemsen, A.T.M., Bartels, A.L., Hendrikse, N.H., Bosker, F.J., den Boer, J.A.
Format: Article
Language:English
Subjects:
Blood
Blood-brain barrier
Medical research
Online Access:Get full text
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Description
Summary:The brain is protected against blood borne toxic influences by the blood-brain barrier, which includes the molecular efflux pump P-glycoprotein (P-gp) in the vessel wall of brain capillaries.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2008.04.209