Striatal dopamine D2 receptor occupancy measurements using [123I]IBZM SPECT and [11C]Raclopride PET: A within-subject comparison study

Methods Twenty schizophrenic patients (10 male, 36.4±10.4 yrs.) on antipsychotic monotherapy with risperidone (n=7; 3-9 mg/d), olanzapine (n=5;5-20 mg/d) or clozapine (n=8;150-450 mg/d) at stable doses, and ten healthy volunteers (5 male, 26.4±6.2 yrs) underwent both a [123I]IBZM SPECT and a [11C]Ra...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2008-01, Vol.41, p.T123
Main Authors: Catafau, Ana M., Bullich, S., Suarez, M., Cot, A., Gunn, R.N., Gallego, J., Pavía, J., Llop, J., Rabiner, E., Ros, D., Laruelle, M.
Format: Article
Language:English
Subjects:
Dopamine
Monte Carlo simulation
Psychotropic drugs
Online Access:Get full text
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Summary:Methods Twenty schizophrenic patients (10 male, 36.4±10.4 yrs.) on antipsychotic monotherapy with risperidone (n=7; 3-9 mg/d), olanzapine (n=5;5-20 mg/d) or clozapine (n=8;150-450 mg/d) at stable doses, and ten healthy volunteers (5 male, 26.4±6.2 yrs) underwent both a [123I]IBZM SPECT and a [11C]Raclopride PET in random order on different days within a week, at the same time after last antipsychotic dose administration. SPECT was acquired at 120 min after a single bolus injection of the radioligand and reconstructed using filtered-backprojection (FBP) (Butterworth filter, exponent=5.0; cuttoff=0.4 cycle/pixel) with a uniform attenuation map.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2008.04.091