Dissociation between striatal alpha4beta2 nicotinic acetylcholine receptors (alpha4beta2) and dopamine transporters (DAT) in Parkinson disease: A 2-[18F]-F-A-85380 PET/[123I]-FP-CIT SPECT study

Nicotine is assumed to have neuroprotective properties in PD, most likely mediated via alpha4beta2. Since alpha4beta2 is highly abundant on presynaptic dopaminergic neurons in the striatum and midbrain, in PD, nigrostriatal DAT degeneration may be paralleled by a reduction of alpha4beta2.

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2006, Vol.31, p.T157-T157
Main Authors: Meyer, Philipp, Hesse, S., Kendziorra, K., Becker, G., Wegner, F., Schildan, A., Seese, A., Lobsien, D., Barthel, H., Schwarz, J., Sabri, O.
Format: Article
Language:English
Subjects:
Brain
Dopamine
Medical research
Parkinson's disease
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Description
Summary:Nicotine is assumed to have neuroprotective properties in PD, most likely mediated via alpha4beta2. Since alpha4beta2 is highly abundant on presynaptic dopaminergic neurons in the striatum and midbrain, in PD, nigrostriatal DAT degeneration may be paralleled by a reduction of alpha4beta2.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2006.04.140