In vivo characterization in non-human primates of [beta]FEmZIENT and [beta]FEmZBrENT: New serotonin transporter imaging agents: effects of selective monoamine transporter displacement using microPET

[...]displacement studies were also carried out by administration of the DAT ligand methylphenidate (0.3 mg/kg) 2 h after injection of [18F]βFEmZIENT and [18F]βFEmZBrENT showed insignificant washout of the radioactivity from brain regions known to be rich in DAT.

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2006-01, Vol.31, p.T27
Main Authors: Goodman, Mark, Stehouwer, J, Jarkas, N, Voll, R, Williams, L, Votaw, J
Format: Article
Language:English
Subjects:
Ligands
Medical imaging
Monkeys & apes
Studies
Online Access:Get full text
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Description
Summary:[...]displacement studies were also carried out by administration of the DAT ligand methylphenidate (0.3 mg/kg) 2 h after injection of [18F]βFEmZIENT and [18F]βFEmZBrENT showed insignificant washout of the radioactivity from brain regions known to be rich in DAT.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2006.04.017