Acute systemic lipopolysaccharide (LPS) produces regional changes in brain sigma-1 receptors as measured with [ 18F]2-Flouropropyl-[(4-cyanophenoxy)methyl]piperidine ([ 18F]FPS) in the rat

After 60 min, animals were humanely killed, and the concentration (%ID/g) of [18F]FPS in blood, heart and select brain regions (striatum, cerebellum,, hippocampus, thalamus, hypothalamus, frontal cortex, temporal cortex and medulla/pons) was determined post-mortem. [...]models should be valuable to...

Full description

Saved in:
Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2006, Vol.31, p.T177-T177
Main Authors: Waterhouse, Rikki N., Chang, R.C., Zhao, J.
Format: Article
Language:English
Subjects:
Behavior
Immune system
Medical research
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:After 60 min, animals were humanely killed, and the concentration (%ID/g) of [18F]FPS in blood, heart and select brain regions (striatum, cerebellum,, hippocampus, thalamus, hypothalamus, frontal cortex, temporal cortex and medulla/pons) was determined post-mortem. [...]models should be valuable to map changes in the sigma receptor system that occur under as a result of immune system activation and may provide evidence for a role such as changes in "sickness behavior", depression, and cognitive distrubances often associated with these conditions.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2006.04.160