Acute systemic lipopolysaccharide (LPS) produces regional changes in brain sigma-1 receptors as measured with [ 18F]2-Flouropropyl-[(4-cyanophenoxy)methyl]piperidine ([ 18F]FPS) in the rat

After 60 min, animals were humanely killed, and the concentration (%ID/g) of [18F]FPS in blood, heart and select brain regions (striatum, cerebellum,, hippocampus, thalamus, hypothalamus, frontal cortex, temporal cortex and medulla/pons) was determined post-mortem. [...]models should be valuable to...

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Published in:NeuroImage (Orlando, Fla.) Fla.), 2006, Vol.31, p.T177-T177
Main Authors: Waterhouse, Rikki N., Chang, R.C., Zhao, J.
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Language:English
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Immune system
Medical research
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Zhao, J.
description After 60 min, animals were humanely killed, and the concentration (%ID/g) of [18F]FPS in blood, heart and select brain regions (striatum, cerebellum,, hippocampus, thalamus, hypothalamus, frontal cortex, temporal cortex and medulla/pons) was determined post-mortem. [...]models should be valuable to map changes in the sigma receptor system that occur under as a result of immune system activation and may provide evidence for a role such as changes in "sickness behavior", depression, and cognitive distrubances often associated with these conditions.
doi_str_mv 10.1016/j.neuroimage.2006.04.160
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subjects Behavior
Immune system
Medical research
title Acute systemic lipopolysaccharide (LPS) produces regional changes in brain sigma-1 receptors as measured with [ 18F]2-Flouropropyl-[(4-cyanophenoxy)methyl]piperidine ([ 18F]FPS) in the rat
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