Orthopoxviruses

Cytolytic T (Tc) lymphocytes are the first order response of the adaptive immune system in the recovery from primary viral infections. These effector cells execute their function either by direct cytotoxicity through the Fas or perforin pathway and/or by the release of cytokines that either directly...

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Bibliographic Details
Published in:Trends in immunology 2004-10, Vol.25 (10), p.524
Main Authors: Müllbacher, Arno, Regner, Matthias, Wang, Yang, Lee, Eva, Lobigs, Mario, Simon, Markus
Format: Article
Language:English
Subjects:
Apoptosis
Defects
Immune system
Infections
Ligands
Medical research
Mortality
Viral infections
Viruses
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Summary:Cytolytic T (Tc) lymphocytes are the first order response of the adaptive immune system in the recovery from primary viral infections. These effector cells execute their function either by direct cytotoxicity through the Fas or perforin pathway and/or by the release of cytokines that either directly or indirectly exert antiviral activity. Mice respond to infection by closely related viruses with a vigorous Tc response, which is characterized by extensive crossreactivity on target cells infected with these viruses. However, the action of these cells can be beneficial, detrimental or neutral. From our current state of knowledge, no generalizations as to protective or detrimental effects of cytolytic effector functions in recovery from virus infections can be made. Thus, virus-host immune interactions have to be assessed individually and cannot be generalized.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2004.08.004