Imaging of D2agonist binding sites in healthy human subjects with [11C]NPA: Preliminary validation and reproducibility studies

Introduction (-)-N-[11C]-Propyl-norapomorphine (NPA) is a full dopamine (DA) D2/3 receptor agonist radiotracer suitable for imaging D2/3 (hereafter referred to as D2) receptors configured in a state of high affinity for agonists with Positron Emission Tomography (PET). [...]the reproducibility of [1...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2008-01, Vol.41, p.T41
Main Authors: Narendran, R, Frankle, WG, Mason, NS, Lopresti, BJ, Laymon, CM, Litschge, M, Vora, SN, Asmonga, D, Mountz, JM, Mathis, CA
Format: Article
Language:English
Subjects:
Binding sites
Dopamine
Medical imaging
Medical research
Methods
Online Access:Get full text
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Summary:Introduction (-)-N-[11C]-Propyl-norapomorphine (NPA) is a full dopamine (DA) D2/3 receptor agonist radiotracer suitable for imaging D2/3 (hereafter referred to as D2) receptors configured in a state of high affinity for agonists with Positron Emission Tomography (PET). [...]the reproducibility of [11C]NPA in the functional subdivisions of the striatum is comparable to that reported for [11C]raclopride (BPND
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2008.04.215