Effect of [alpha]- and [gamma]-polymorphs of glycine on the intranasal delivery of manganese hydroxide nanoparticles into brain structures

The purpose of this work was to perform a comparative study of the effect of solutions of polymorphic modifications of glycine on the efficiency of transport of nanoparticles into the brain. Freezing and subsequent heating of glycine solutions completely disturbs their structure, which no longer dep...

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Bibliographic Details
Published in:Doklady. Biochemistry and biophysics 2014-01, Vol.454 (1), p.6
Main Authors: Achkasov, A F, Boldyreva, E V, Bukhtiyarov, V I, Zapara, T A, Losev, E A, Moshkin, M P, Ratushnyak, A S, Romashchenko, A V, Troitskii, S Yu, Boldyrev, V V
Format: Article
Language:English
Subjects:
Biochemistry
Biophysics
Nanoparticles
Neurology
Polymorphism
Online Access:Get full text
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Summary:The purpose of this work was to perform a comparative study of the effect of solutions of polymorphic modifications of glycine on the efficiency of transport of nanoparticles into the brain. Freezing and subsequent heating of glycine solutions completely disturbs their structure, which no longer depends on the polymorphic form that was used to prepare the solution.
ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672914010037